Синдром на полиневропатия, органомегалия, едрокринопатия, м-протеин и кожни промени (POEMS) – клиничен случай
Ключови думи:
https://doi.org/10.67667/NEU.v25i2.177Ключови думи:
POEMS, полиневропатияАбстракт
Синдромът на полиневропатия (ПНП), органомегалия, ендокринопатия, М-протеин и кожни промени (POEMS) е рядък паранеопластичен синдром, свързан с плазмоклетъчна дискразия. Представяме клиничен случай на POEMS със специфична подостра болезнена ПНП, загуба на тегло, диария, кожни промени, отоци, JAK2 негативна полицитемия и М-протеин.
Заключение: Всеки случай на специфична подостра болезнена сензомоторна ПНП, особено при наличие на характерни костни и кожни промени, изисква изследване за POEMS.
Литература
Bardwick, P.A., Zvaifler, N.J., Gill, G.N., Newman, D., Greenway, G.D., Resnick, D.L. Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore), 1980, 59, 4, 311-322.
Brown, R., Ginsberg, L. POEMS syndrome: clinical update. J Neurol, 2019, 266, 1, 268-277.
Dao, L.N., Hanson, C.A., Dispenzieri, A., Morice, W.G., Kurtin, P.J., Hoyer, J.D. Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients. Blood, 2011, 117, 24, 6438-6444.
Dispenzieri, A. POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management. Am J Hematol, 2017, 92, 814-829.
Dispenzieri, A. POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management. Am J Hematol, 2019, 94, 7, 812-827.
Dispenzieri, A. POEMS syndrome: 2021 Update on diagnosis, risk-stratification, and management. Am J Hematol., 2021, 96, 7, 872-888.
Dispenzieri, A., Fajgenbaum, D.C. Overview of Castleman disease. Blood, 2020,135, 16, 1353-1364.
D'Souza, A., Hayman, S.R., Buadi, F., Mauermann, M., Lacy, M.Q., Gertz, M.A., Kyle, R.A., Kumar, S., Greipp, P.R., Lust, J.A., Russell, S.J., Zeldenrust, S., Dingli, D., Witzig, T.E., Rajkumar, S.V., Dispenzieri, A. The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome. Blood, 2011, 118, 17, 4663-4665.
Farrugia, D., Camilleri, D.J., Azzopardi, J., Camilleri, F. POEMS syndrome: a unique presentation and a diagnostic challenge. BMJ Case Rep., 2019, 12, 12, e230284.
Gangat, N., Szuber, N., Pardanani, A., Tefferi, A. JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views. Leukemia, 2021, 35, 2166-2181.
Kim, Y.R. Update on the POEMS syndrome. Blood Res., 2022, 57, S1, 27-31.
Kulkarni, G.B., Mahadevan, A., Taly, A.B., Yasha, T.C., Seshagiri, K.S., Nalini, A., Satishchandra, P., Veerendrakumar, M., Shankar, S.K. Clinicopathological profile of polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes (POEMS) syndrome. J Clin Neurosci., 2011, 18, 3, 356-360.
Li, J., Zhou, D.B., Huang, Z., Jiao, L., Duan, M.H., Zhang, W., Zhao, Y.Q., Shen, T. Clinical characteristics and long-term outcome of patients with POEMS syndrome in China. Ann Hematol., 2011, 90, 7, 819-826.
Miest, R.Y., Comfere, N.I., Dispenzieri, A., Lohse, C.M., el-Azhary, R.A. Cutaneous manifestations in patients with POEMS syndrome. Int J Dermatol., 2013, 52, 11, 1349-1356.
Nasu, S., Misawa, S., Sekiguchi, Y., Shibuya, K., Kanai, K., Fujimaki, Y., Ohmori, S., Mitsuma, S., Koga, S., Kuwabara, S. Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy. J Neurol Neurosurg Psychiatry, 2012, 83, 3, 476-479.
Rahul, K., Handa, N., Chandrashekhara, S.H., Usha, T., Singh, A. An Atypical Case of POEMS Syndrome with an Osteolytic Bone Lesion. J Clin Diagn Res., 2015, 9, 6, XD01-XD02.
Szczerkowska-Dobosz, A., Olszewska, B., Lemańska, M., Purzycka-Bohdan, D., Nowicki, R. Acquired facial lipoatrophy: pathogenesis and therapeutic options. Postepy Dermatol Alergol., 2015, 32, 2, 127-133.
Suichi, T., Misawa, S., Beppu, M., Takahashi, S., Sekiguchi, Y., Shibuya, K., Amino, H., Tsuneyama, A., Suzuki, Y.I., Nakamura, K., Sato, Y., Kuwabara, S. Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey. Neurology, 2019, 93, 10, e975-e983.
Публикуван
Как да цитирате?
Брой
Раздел (Секция)
ARK
Лиценз
Copyright (c) 2025 Българска Неврология
Публикация с Creative Commons Attribution 4.0 International License.
