Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome (POEMS) – case report

Authors

Keywords:

POEMS, polyneuropathy

Abstract

Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome (POEMS) is a rare paraneoplastic syndrome, associated with plasma cell dyscrasia. We present a clinical case of POEMS syndrome with specific subacute painful polyneuropathy, weight loss, diarrhea, edema, JAK2 negative polycythemia and Mprotein.
Conclusion: POEMS should be considered incases with specific subacute painful sensory and motor polyneuropathy and characteristic bone lesions or skin changes.

References

Bardwick, P.A., Zvaifler, N.J., Gill, G.N., Newman, D., Greenway, G.D., Resnick, D.L. Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore), 1980, 59, 4, 311-322.

Brown, R., Ginsberg, L. POEMS syndrome: clinical update. J Neurol, 2019, 266, 1, 268-277.

Dao, L.N., Hanson, C.A., Dispenzieri, A., Morice, W.G., Kurtin, P.J., Hoyer, J.D. Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients. Blood, 2011, 117, 24, 6438-6444.

Dispenzieri, A. POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management. Am J Hematol, 2017, 92, 814-829.

Dispenzieri, A. POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management. Am J Hematol, 2019, 94, 7, 812-827.

Dispenzieri, A. POEMS syndrome: 2021 Update on diagnosis, risk-stratification, and management. Am J Hematol., 2021, 96, 7, 872-888.

Dispenzieri, A., Fajgenbaum, D.C. Overview of Castleman disease. Blood, 2020,135, 16, 1353-1364.

D'Souza, A., Hayman, S.R., Buadi, F., Mauermann, M., Lacy, M.Q., Gertz, M.A., Kyle, R.A., Kumar, S., Greipp, P.R., Lust, J.A., Russell, S.J., Zeldenrust, S., Dingli, D., Witzig, T.E., Rajkumar, S.V., Dispenzieri, A. The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome. Blood, 2011, 118, 17, 4663-4665.

Farrugia, D., Camilleri, D.J., Azzopardi, J., Camilleri, F. POEMS syndrome: a unique presentation and a diagnostic challenge. BMJ Case Rep., 2019, 12, 12, e230284.

Gangat, N., Szuber, N., Pardanani, A., Tefferi, A. JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views. Leukemia, 2021, 35, 2166-2181.

Kim, Y.R. Update on the POEMS syndrome. Blood Res., 2022, 57, S1, 27-31.

Kulkarni, G.B., Mahadevan, A., Taly, A.B., Yasha, T.C., Seshagiri, K.S., Nalini, A., Satishchandra, P., Veerendrakumar, M., Shankar, S.K. Clinicopathological profile of polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes (POEMS) syndrome. J Clin Neurosci., 2011, 18, 3, 356-360.

Li, J., Zhou, D.B., Huang, Z., Jiao, L., Duan, M.H., Zhang, W., Zhao, Y.Q., Shen, T. Clinical characteristics and long-term outcome of patients with POEMS syndrome in China. Ann Hematol., 2011, 90, 7, 819-826.

Miest, R.Y., Comfere, N.I., Dispenzieri, A., Lohse, C.M., el-Azhary, R.A. Cutaneous manifestations in patients with POEMS syndrome. Int J Dermatol., 2013, 52, 11, 1349-1356.

Nasu, S., Misawa, S., Sekiguchi, Y., Shibuya, K., Kanai, K., Fujimaki, Y., Ohmori, S., Mitsuma, S., Koga, S., Kuwabara, S. Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy. J Neurol Neurosurg Psychiatry, 2012, 83, 3, 476-479.

Rahul, K., Handa, N., Chandrashekhara, S.H., Usha, T., Singh, A. An Atypical Case of POEMS Syndrome with an Osteolytic Bone Lesion. J Clin Diagn Res., 2015, 9, 6, XD01-XD02.

Szczerkowska-Dobosz, A., Olszewska, B., Lemańska, M., Purzycka-Bohdan, D., Nowicki, R. Acquired facial lipoatrophy: pathogenesis and therapeutic options. Postepy Dermatol Alergol., 2015, 32, 2, 127-133.

Suichi, T., Misawa, S., Beppu, M., Takahashi, S., Sekiguchi, Y., Shibuya, K., Amino, H., Tsuneyama, A., Suzuki, Y.I., Nakamura, K., Sato, Y., Kuwabara, S. Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey. Neurology, 2019, 93, 10, e975-e983.

Published

30.11.2024

How to Cite

Valkova, M., Tzolova, E., & Guergueltcheva, V. (2024). Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome (POEMS) – case report. Bulgarian Neurology, 25(2), 77–78. Retrieved from https://www.nevrologiabg.com/journal/index.php/neurology/article/view/177

ARK