Non-atherosclerotic intracranial stenoses – a cause of ischemic stroke in young patients
Keywords:
Intracranial stenosis, atherosclerosis, non-atherosclerotic intracranial stenosis, ischaemic stroke etiology, evolution, prognosisAbstract
Intracranial atherosclerotic stenoses (ICAS) are one of the most common etiologies of cerebrovascular ischaemic events worldwide. Modern neuroimaging techniques in recent years have provided new insights not only into ICAS, but also into the underlying pathophysiological mechanisms of ICAS-related strokes. Non-atherosclerotic intracranial stenoses are a heterogenous group, representing multiple distinct diseases with different etiology, pathophysiology, clinical course, therapeutic approach and prognosis.
We present a case report of a young female with ischaemic stroke and bilateral severe non-atherosclerotic intracranial stenoses. A transcranial color-coded duplex sonography performed five years later revealed severe progression of the stenosis of the left middle cerebral artery, which was also confirmed by magnetic resonance angiography. However, during the long-term 12-year follow-up the patient remained asymptomatic.
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