A case of a 4-year-old girl with multiphase adem and positive anti-mog antibodies
Keywords:
anti-MOG antibody, encephalitis, ADEM, epileptic seizure, MRT, multiphasic disseminated encephalomyelitis (MDEM)Abstract
Acute disseminated encephalomyelitis (ADEM) or acute demyelinating encephalomyelitis is a rare immunomediated disease, with a common trigger viral or bacterial infection leading to extensive areas of inflammation and demyelination in the brain and / or spinal cord, with a predominant manifestation in childhood. It usually occurs as a single episode and has a favorable prognosis. In a small percentage of cases, children have a subsequent episodes and in this cases the disease should be differentiated from children’s MS. Multiphase ADEM should always be considered as a risk factor for future other demyelinating disease, especially in cases of anti-MOG positive and persistent antibodies.
References
Bozhinova, V., Deneva, D., Asenova, A., Koleva, M., Rodopska, E., Topalov, N. Avtoimunni encefaliti v detskata vyzrast – kriterii i algoritym za diagnostika i lechenie. Bylgarska nevrologiia. 20147,18, 3, 194-200. https://www.nevrologiabg.com/journal/index.php/neurology/issue/view/74/84
Georgiev, D. 4.2 Ostyr diseminiran encefalomielit(ODEM). V: Nevrologiia. Pod red. Na akad. prof. d-r Ivan Milanov, dmn. 609-610. 3. Milanov, I., Bozhinova, V., Ivanov, I. Nacionalen konsensus za diagnostika i lechenie na ostri i avtoimunni encefaliti i virus inducirani encefalopatii 2019 g. Bylgarska nevrologiia. 2019, 20, 3. https://www.nevrologiabg.com/journal/index.php/neurology/issue/view/80/90
Anilkumar, A., Foris, L., Tadi, P. Acute Disseminated Encephalo - myelitis. Stat Pearls Publishing, 2020.
Anlar, B., Basaran, C., Kose, G. Acute Disseminated Encephalo - myelitis in Children: Outcome and Prognosis. Neuropediatrics 2003, 34, 4, 194-199.
Baumann, M., Hennes, EM., Schanda, K. et al. Children with multiphasic disseminated encephalomyelitis and antibodies to the myelin oligodendrocyte glycoprotein (MOG): Extending the spectrum of MOG antibody positive diseases. Mult Scler. 2016, 22, 14, 1821-1829.
Bennetto, L., Scolding, N. Inflammatory/post-infectious encephalomyelitis. Journal of Neurology, Neurosurgery and Psychiatry. 75, 1, 22-28.
De Mol, C.L., Wong, Y.Y.M., van Pelt, E.D. et al. The clinical spectrum and incidence of anti-MOG-associated acquired demyelinating syndromes in children and adults. Mult Scler. 2020, 26, 7, 806-814.
Duignan, S., Wright, S., Rossor, T., et al. Myelin oligodendrocyte glycoprotein and aquaporin-4 antibodies are highly specific in children with acquired demyelinating syndromes. Dev Med Child Neurol 2018, 60, 958-962.
Fukushima, N., Suzuki, M., Ogawa, R. et al. A case of anti-MOG antibody-positive multiphasic disseminated encephalomyelitis cooccurring with unilateral cerebral cortical encephalitis. Rinsho Shinkeigaku. 2017, 57, 11, 723-728.
Spadaro, M., Gerdes, L.A, Krumbholz M, et al. Autoantibodies to MOG in a distinct subgroup of adult multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 2016, 3, 5, 257.
Tenembaum, S., Waters, P., Leite, M. et al. Spectrum of MOG Autoantibody-Associated Inflammatory Diseases in Pediatric Patients. Neurology. 2015, 84, 14.
Downloads
Published
How to Cite
Issue
Section
ARK
License
Copyright (c) 2020 Maya Koleva
This work is licensed under a Creative Commons Attribution 4.0 International License.
