Cognitive functioning in middle age
Keywords:
cognitive functioning, neuroimaging, risk factors, middle age, CANTABAbstract
The aim of the study was to determine the influence of certain vascular risk factors (VRF) on cognitive functioning in clinically healthy middle-aged individuals and to assess the difference in cognitive test results (CANTAB) depending on the presence / absence of asymptomatic findings for cerebrovascular disease (CVD) from Doppler sonography of cerebral vessels (DS) and magnetic resonance imaging of the brain (MRI). Contingent and
Methods: The study included 98 healthy adults between 45 and 55 years of age with normal daily functioning according to selected criteria. After neurological examination, blood tests, DS and MRI, participants were tested with the computer neuropsychological battery CANTAB. Subtests SWM, SOC and IED was used. In order to establish associations between VRF and CANTAB measures, multiple linear regression analysis was applied.
Results:
We found: 1) significant negative impact of available VRF on several measures assessing the performance in the SOC and SWM subtests, as well as on the overall result of CANTAB; 2) participants without abnormal DS findings show a better result than those with DS findings in terms of one measure from the SOC subtest; those without asymptomatic cerebral infarctions (ACI) performed better on three other measures from the SOC and SWM subtests of the group examined by MRI. Conclusion: In middle-aged individuals with normal daily functioning, the present study found a worse performance in a CANTAB study depending on the presence of VRF. Therefore, the subjects are at risk of developing early cognitive impairments (CI), which suggest the later development of more severe dementia. The measures reported and analyzed from the SOC and SWM subtests of CANTAB „indicate” the presence of asymptomatic findings for CVD from a study with DS and MRI of the brain. Their predictive ability underscores the importance of neuropsychological methods for screening for early cognitive impairment in middle age and the need for controlled prevention of VRF.
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Copyright (c) 2020 Kostadin Chompalov, K. Bahchevanov, P. Atanassova
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