Polyneuropathy, organomegaly, endoCrinopathy, m protein and skin changes syndrome (POEMS) – literature review
Keywords:
POEMS, polyneuropathyAbstract
Polyneuropathy, organomegaly, endocrinopathy, M-protein and skin changes syndrome (POEMS) is a rare paraneoplastic syndrome, associated with plasma cell dyscrasia. POEMS involves several clinical signs and symptoms with varying presentation. The first and most prominent of them is the subacute painful sensory and motor polyneuropathy. The diagnosis is based on Dispenzieri criteria (2017). Differential diagnosis involves chronic demyelinating polyneuropathy, amyloidosis, monoclonal gammopathy of undetermined significance, chronic hepatitis, Humman Immunodeficiency Virus and other paraneoplastic syndromes. The treatment is interdisciplinary.
References
Bardwick, P.A., Zvaifler, N.J., Gill, G.N., Newman, D., Greenway, G.D., Resnick, D.L. Plasma cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes: the POEMS syndrome. Report on two cases and a review of the literature. Medicine (Baltimore), 1980, 59, 4, 311-322.
Brown, R., Ginsberg, L. POEMS syndrome: clinical update. J Neurol, 2019, 266, 1, 268-277.
Dao, L.N., Hanson, C.A., Dispenzieri, A., Morice, W.G., Kurtin, P.J., Hoyer, J.D. Bone marrow histopathology in POEMS syndrome: a distinctive combination of plasma cell, lymphoid, and myeloid findings in 87 patients. Blood, 2011, 117, 24, 6438-6444.
Dispenzieri, A. POEMS syndrome: 2017 Update on diagnosis, risk stratification, and management. Am J Hematol, 2017, 92, 814-829.
Dispenzieri, A. POEMS Syndrome: 2019 Update on diagnosis, risk-stratification, and management. Am J Hematol, 2019, 94, 7, 812-827.
Dispenzieri, A. POEMS syndrome: 2021 Update on diagnosis, risk-stratification, and management. Am J Hematol., 2021, 96, 7, 872-888.
Dispenzieri, A., Fajgenbaum, D.C. Overview of Castleman disease. Blood, 2020,135, 16, 1353-1364.
D'Souza, A., Hayman, S.R., Buadi, F., Mauermann, M., Lacy, M.Q., Gertz, M.A., Kyle, R.A., Kumar, S., Greipp, P.R., Lust, J.A., Russell, S.J., Zeldenrust, S., Dingli, D., Witzig, T.E., Rajkumar, S.V., Dispenzieri, A. The utility of plasma vascular endothelial growth factor levels in the diagnosis and follow-up of patients with POEMS syndrome. Blood, 2011, 118, 17, 4663-4665.
Farrugia, D., Camilleri, D.J., Azzopardi, J., Camilleri, F. POEMS syndrome: a unique presentation and a diagnostic challenge. BMJ Case Rep., 2019, 12, 12, e230284.
Gangat, N., Szuber, N., Pardanani, A., Tefferi, A. JAK2 unmutated erythrocytosis: current diagnostic approach and therapeutic views. Leukemia, 2021, 35, 2166-2181.
Kim, Y.R. Update on the POEMS syndrome. Blood Res., 2022, 57, S1, 27-31.
Kulkarni, G.B., Mahadevan, A., Taly, A.B., Yasha, T.C., Seshagiri, K.S., Nalini, A., Satishchandra, P., Veerendrakumar, M., Shankar, S.K. Clinicopathological profile of polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes (POEMS) syndrome. J Clin Neurosci., 2011, 18, 3, 356-360.
Li, J., Zhou, D.B., Huang, Z., Jiao, L., Duan, M.H., Zhang, W., Zhao, Y.Q., Shen, T. Clinical characteristics and long-term outcome of patients with POEMS syndrome in China. Ann Hematol., 2011, 90, 7, 819-826.
Miest, R.Y., Comfere, N.I., Dispenzieri, A., Lohse, C.M., el-Azhary, R.A. Cutaneous manifestations in patients with POEMS syndrome. Int J Dermatol., 2013, 52, 11, 1349-1356.
Nasu, S., Misawa, S., Sekiguchi, Y., Shibuya, K., Kanai, K., Fujimaki, Y., Ohmori, S., Mitsuma, S., Koga, S., Kuwabara, S. Different neurological and physiological profiles in POEMS syndrome and chronic inflammatory demyelinating polyneuropathy. J Neurol Neurosurg Psychiatry, 2012, 83, 3, 476-479.
Rahul, K., Handa, N., Chandrashekhara, S.H., Usha, T., Singh, A. An Atypical Case of POEMS Syndrome with an Osteolytic Bone Lesion. J Clin Diagn Res., 2015, 9, 6, XD01-XD02.
Szczerkowska-Dobosz, A., Olszewska, B., Lemańska, M., Purzycka-Bohdan, D., Nowicki, R. Acquired facial lipoatrophy: pathogenesis and therapeutic options. Postepy Dermatol Alergol., 2015, 32, 2, 127-133.
Suichi, T., Misawa, S., Beppu, M., Takahashi, S., Sekiguchi, Y., Shibuya, K., Amino, H., Tsuneyama, A., Suzuki, Y.I., Nakamura, K., Sato, Y., Kuwabara, S. Prevalence, clinical profiles, and prognosis of POEMS syndrome in Japanese nationwide survey. Neurology, 2019, 93, 10, e975-e983.