Sleep disorders in patients with myasthenia gravis
Keywords:
Myasthenia gravis, sleep disorders, sleep apnea, insomnia, movement disordersAbstract
Myasthenia gravis (MG) is an autoimmune disease caused by the presence of antibodies against acetylcholine receptors (AChR), muscle-specific tyrosine kinase (MuSK) and other related proteins in the postsynaptic membrane. The main manifestations of the disease are the pathological muscle fatigue of the striated muscles and muscle weakness due to impaired nerve impulse transmission. Many MG patients suffer from various sleep disorders. In neuromuscular diseases, including MG, the most common are sleep breathing disorders such as sleep apnea, insomnia and movement disorders. They can aggravate the underlying disease, worsen the quantity and quality of sleep, which makes them socially significant. It is important to think about them in order to be timely diagnosed and treated.
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