Sudden unexpected death in epilepsy (SUDEP)
Keywords:Sudden unexpected death in epilepsy, Рathophysiology, Тonic-clonic seizures
Epilepsy is one of the most common neurological disorders and affects approximately 50 million people worldwide. While the spectrum of comorbidity varies significantly among patients with epilepsy, there is an overall increased mortality risk in this population. Causes of death in individuals with epilepsy include non-epilepsy-related conditions such as suicide, cancers, and cardiovascular disease, as well as epilepsy-related provoked causes, including status epilepticus, anti-seizure drug effects, motor vehicle and bicycle accidents, alcohol withdrawal, aspirational pneumonia, and drowning. Sudden unexpected death in epilepsy (SUDEP) has been defined as the sudden, unexpected, witnessed or unwitnessed, nontraumatic, and nondrowning death in patients with epilepsy, with or without evidence for a seizure, with exclusion of documented status epilepticus, and when postmortem examination does not reveal a structural or toxicological cause for death. SUDEP is by far the most common and important epilepsy related cause of death and its prevention of great concern for people with epilepsy and their families.
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