Guillain-Barre syndrome during COVID-19 pandemic. Case reports


  • Nikolina Semerdjieva MHATNP "St.Naum"; Medical university – Sofia
  • D. Atanassova UHATNP "St.Naum"; Medical university – Sofia
  • D. Taskov UHATNP „St. Naum”
  • I. Antova UHATNP „St. Naum”
  • M. Milanova UHATNP "St.Naum"; Medical university – Sofia


Guillain-Barre Syndrome, COVID-19, vaccines


Guillain-Barré syndrome often develops as an immune reaction after exposure to certain viral or bacterial antigens, or vaccines. Increasing number of cases have been reported developing during COVID-19 infection, with neurological symptoms beginning on average about 9 days after the onset of the respiratory disease. Isolated cases of Guillain-Barré syndrome have been reported after recovering from COVID-19, and it is hypothesized that the syndrome differs in pathogenesis depending on the time of developing neurological manifestation in the course of the main infectious process. The incidence of Guillain-Barré syndrome has also increased following SARS-Cov-2 vaccination, mainly following the ChAdOx1nCoV-19 vaccine. Despite increasing the risk after vaccination, the risk of developing neurological complications, including Guillain-Barré syndrome, after a positive SARSCoV-2 test remains significantly higher. We present two cases of Guillain-Barré syndrome – the first one – after recovering from COVID-19 and the second one – after vaccination.


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How to Cite

Semerdjieva, N., Atanassova, D., Taskov, D., Antova, I., & Milanova, M. (2021). Guillain-Barre syndrome during COVID-19 pandemic. Case reports. Bulgarian Neurology, 22(2), 76–79. Retrieved from